One example is, the diversion of methadone and buprenorphine from opioid agonist remedy is documented to get a major difficulty in some nations (see Segment Artificial opioid trafficking). On top of that, we see a craze of fall in cost from 2014 to 2019 of some opioids such as heroin, https://bookmarkplaces.com/story18224788/heroin-for-sale-in-usa-for-dummies