The most important circulating metabolite of ketamine (norketamine) demonstrated action at precisely the same receptor with much less affinity. Norketamine is about 1/3 as Energetic as ketamine in reducing halothane demands (MAC) of your rat. A sort of ketamine often known as esketamine nasal spray was accepted through the FDA https://ketalinic.com/ketamine-powder-nasal-spray-vials/