Chemotherapy was potentiated by E7449 and single agent had important antitumor exercise in BRCA-deficient xenografts. Additionally, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile strains, most likely through TNKS inhibition. According to this probability, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization and substantially altered expression of ... https://johne186vae9.wikiap.com/user