In contrast to the other kinds of hypersensitivity reactions, form IV reactions are cell-mediated and antibody-unbiased. They are the 2nd most popular type of hypersensitivity reaction and frequently acquire 2 or more times to acquire. These kinds of reactions are a result of the overstimulation of T cells and monocytes/macrophages https://directivepublications.org/journal-of-immunology/